EFFECTS OF LONG-TERM SENSORY VS SYMPATHETIC DENERVATION ON THE DISTRIBUTION OF CALCITONIN GENE-RELATED PEPTIDE AND TYROSINE-HYDROXYLASE IMMUNOREACTIVITIES IN THE RAT LUNG

被引：21

作者：

VANRANST, L ^{[1
]}

LAUWERYNS, JM ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN, FAC MED, HISTOPATHOL LAB, MINDERBROEDERSSTR 12, B-3000 LOUVAIN, BELGIUM

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1990年 / 29卷 / 1-3期

关键词：

Calcitonin gene-related peptide; Chemosympathectomy; Immunoperoxidase method; Infranodosal vagotomy; Lung; rat; Tyrosine hydroxylase;

D O I：

10.1016/0165-5728(90)90155-G

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study the effect of long-term selective sensory vs. sympathetic denervation was examined in the rat lung. Immunoreactivities for calcitonin gene-related peptide (CGRP) on the one hand and tyrosine hydroxylase (TH) on the other, were used as indexes to asses the changes in the two nerve systems. Following long-term chemosympathectomy a marked increase of CGRP-immunoreactive nerve fibers was seen in the sections, while TH-immunoreactive nerve fibers appeared depleted. Inversely, long-term sensory denervation resulted in an increase of TH-immunoreactive nerve fibers with a sharp decrease of CGRP-immunostained fibers. These results suggest a peripheral interaction between these innervation systems in the lung, the mechanism of which has still to be elucidated. © 1990.

引用

页码：131 / 138

页数：8

共 37 条

[1] REDUCTION OF NEUROPEPTIDE-Y (NPY) IN THE RABBIT IRIS-CILIARY BODY AFTER CHRONIC SYMPATHECTOMY [J].

ALLEN, JM ;

MCGREGOR, GP ;

ADRIAN, TE ;

BLOOM, SR ;

ZHANG, SQ ;

ENNIS, KW ;

UNGER, WG .

EXPERIMENTAL EYE RESEARCH, 1983, 37 (02) :213-215

[2] OCCURRENCE, DISTRIBUTION AND ONTOGENY OF CGRP IMMUNOREACTIVITY IN THE RAT LOWER RESPIRATORY-TRACT - EFFECT OF CAPSAICIN TREATMENT AND SURGICAL DENERVATIONS [J].

CADIEUX, A ;

SPRINGALL, DR ;

MULDERRY, PK ;

RODRIGO, J ;

GHATEI, MA ;

TERENGHI, G ;

BLOOM, SR ;

POLAK, JM .

NEUROSCIENCE, 1986, 19 (02) :605-+

[3]

CARVALHO TLL, 1986, J ANAT, V149, P121

[4] INCREASE IN SP-LIKE IMMUNOREACTIVITY IN NERVE-FIBERS OF RABBIT IRIS AND CILIARY BODY ONE TO 4 MONTHS FOLLOWING SYMPATHETIC DENERVATION [J].

COLE, DF ;

BLOOM, SR ;

BURNSTOCK, G ;

BUTLER, JM ;

MCGREGOR, GP ;

SAFFREY, MJ ;

UNGER, WG ;

ZHANG, SQ .

EXPERIMENTAL EYE RESEARCH, 1983, 37 (02) :191-197

[5] BOMBESIN, CALCITONIN AND LEU-ENKEPHALIN IMMUNOREACTIVITY IN ENDOCRINE-CELLS OF HUMAN-LUNG [J].

CUTZ, E ;

CHAN, W ;

TRACK, NS .

EXPERIENTIA, 1981, 37 (07) :765-767

[6] LOCALIZATION OF SOMATOSTATIN-LIKE, BOMBESIN-LIKE, AND SEROTONIN-LIKE IMMUNOREACTIVITY IN THE LUNG OF THE FETAL RHESUS-MONKEY [J].

DAYER, AM ;

DEMEY, J ;

WILL, JA .

CELL AND TISSUE RESEARCH, 1985, 239 (03) :621-625

[7]

JOH TH, 1983, IMMUNOHISTOCHEMISTRY, P121

[8]

KESSLER JA, 1983, J NEUROSCI, V3, P1301

[9] SUBSTANCE-P LEVELS DIFFER IN SYMPATHETIC TARGET ORGAN TERMINALS AND GANGLION PERIKARYA [J].

KESSLER, JA ;

BELL, WO ;

BLACK, IB .

BRAIN RESEARCH, 1983, 258 (01) :144-146

[10] NEURO-EPITHELIAL BODIES (NEURORECEPTOR OR SECRETORY ORGANS) IN HUMAN INFANT BRONCHIAL AND BRONCHIOLAR EPITHELIUM [J].

LAUWERYN.MJ ;

PEUSKENS, JC .

ANATOMICAL RECORD, 1972, 172 (03) :471-+

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