A VNTR IMMEDIATELY ADJACENT TO THE HUMAN PSEUDOAUTOSOMAL TELOMERE

被引：27

作者：

INGLEHEARN, CF ^{[1
]}

COOKE, HJ ^{[1
]}

机构：

[1] WESTERN GEN HOSP,MRC,HUMAN GENET UNIT,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND

来源：

NUCLEIC ACIDS RESEARCH | 1990年 / 18卷 / 03期

关键词：

D O I：

10.1093/nar/18.3.471

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The probe 29C1 detects a hypervariable locus 18kb from the telomere of the human X and Y chromosomes, in the pseudoautosomal region. Here we report that hypervariability of fragments containing this sequence in the human population arises by loss or gain of a 31 base pair GC rich repeat. Labelled 29C1 does not detect a DNA fingerprint at low stringency, though the consensus repeat sequence does show some similarity to previously reported minisatellites. Sequence within the repeat block has G and C rich strands, a feature associated with sequences at the telomeres of many higher organisms. The repeat block shows sequence characteristics normally associated with a low methylation island, though the locus is methylated and does not appear to be transcribed. © 1990 Oxford University Press.

引用

页码：471 / 476

页数：6

共 49 条

[1] TELOMERIC REPEAT FROM T-THERMOPHILA CROSS HYBRIDIZES WITH HUMAN TELOMERES [J].

ALLSHIRE, RC ;

GOSDEN, JR ;

CROSS, SH ;

CRANSTON, G ;

ROUT, D ;

SUGAWARA, N ;

SZOSTAK, JW ;

FANTES, PA ;

HASTIE, ND .

NATURE, 1988, 332 (6165) :656-659

[2]

BALAZS I, 1986, AM J HUM GENET, V39, P229

[3] THE HIGHLY POLYMORPHIC REGION NEAR THE HUMAN INSULIN GENE IS COMPOSED OF SIMPLE TANDEMLY REPEATING SEQUENCES [J].

BELL, GI ;

SELBY, MJ ;

RUTTER, WJ .

NATURE, 1982, 295 (5844) :31-35

[4] CPG-RICH ISLANDS AND THE FUNCTION OF DNA METHYLATION [J].

BIRD, AP .

NATURE, 1986, 321 (6067) :209-213

[5] TELOMERES - DO THE ENDS JUSTIFY THE MEANS [J].

BLACKBURN, EH .

CELL, 1984, 37 (01) :7-8

[6] DNA FINGERPRINTING IN BIRDS [J].

BURKE, T ;

BRUFORD, MW .

NATURE, 1987, 327 (6118) :149-152

[7] COMPLETE NUCLEOTIDE-SEQUENCES OF THE T24 HUMAN BLADDER-CARCINOMA ONCOGENE AND ITS NORMAL HOMOLOG [J].

CAPON, DJ ;

CHEN, EY ;

LEVINSON, AD ;

SEEBURG, PH ;

GOEDDEL, DV .

NATURE, 1983, 302 (5903) :33-37

[8] HYPERVARIABLE MINISATELLITE REGIONS ARE SITES FOR CROSSING-OVER AT MEIOSIS IN MAN [J].

CHANDLEY, AC ;

MITCHELL, AR .

CYTOGENETICS AND CELL GENETICS, 1988, 48 (03) :152-155

[9] HYPERVARIABLE TELOMERIC SEQUENCES FROM THE HUMAN SEX-CHROMOSOMES ARE PSEUDOAUTOSOMAL [J].

COOKE, HJ ;

BROWN, WRA ;

RAPPOLD, GA .

NATURE, 1985, 317 (6039) :687-692

[10]

COOKE HJ, 1986, COLD SPRING HARB SYM, V51, P213, DOI 10.1101/SQB.1986.051.01.026

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