CONGENITAL HYDROCEPHALUS AND EYE ABNORMALITIES WITH SEVERE DEVELOPMENTAL BRAIN DEFECTS - WARBURGS SYNDROME

Five patients are reported with Warburg''s syndrome, characterized by: congenital hydrocephalus; severe neonatal neurological dysfunction; abnormalities of the anterior and posterior chambers of the eyes; absence of known cause; and severe developmental abnormalities of cortical gyration and architectonics. The syndrome can be diagnosed during life on the conjunction of the first 4 features listed. Evidently this syndrome is a genetically determined condition with an autosomal recessive mode of inheritance and with a 25% recurrence risk for offspring of the parents of an affected infant.