A LONG-RANGE RESTRICTION MAP OF THE INTERLEUKIN-4 AND INTERLEUKIN-5 LINKAGE GROUP ON CHROMOSOME-5

被引：31

作者：

CHANDRASEKHARAPPA, SC

REBELSKY, MS

FIRAK, TA

LEBEAU, MM

WESTBROOK, CA

机构：

[1] Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago

来源：

GENOMICS | 1990年 / 6卷 / 01期

关键词：

D O I：

10.1016/0888-7543(90)90452-Z

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The genes for two of the hematopoietic growth factors, interleukin-4 and interleukin-5, are located on a small segment of chromosome 5 (q23-31), which is frequently deleted in myeloid disorders. Using pulsedfield gel electrophoresis, we demonstrate physical linkage of these two genes and present a long-range restriction map of the locus. The two genes are closely linked (maximum separation, 310 kb) and appear to be separated by an HTF island. We were unable to physically link these genes to two other closely related hematopoietic growth factor genes, interleukin-3 and granulocyte/macrophage colony-stimulating factor, which also map to this region of the genome. The clustering of these and other growth-related genes suggests that a higher order of genetic organization exists in this region of the chromosome. © 1990.

引用

页码：94 / 99

页数：6

共 25 条

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