A FAMILY OF AMPA-SELECTIVE GLUTAMATE RECEPTORS

被引：1311

作者：

KEINANEN, K

WISDEN, W

SOMMER, B

WERNER, P

HERB, A

VERDOORN, TA

SAKMANN, B

SEEBURG, PH

机构：

[1] UNIV HEIDELBERG, CTR MOLEC BIOL, MOLEC NEUROENDOCRINOL LAB, W-6900 HEIDELBERG, GERMANY

[2] MAX PLANCK INST MED RES, ZELLPHYSIOL ABT, W-6900 HEIDELBERG 1, GERMANY

来源：

SCIENCE | 1990年 / 249卷 / 4968期

关键词：

D O I：

10.1126/science.2166337

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library. In situ hybridization revealed differential expression patterns of the cognate mRNAs throughout the brain. Functional expression of the cDNAs in cultured mammalian cells generated receptors displaying α-amino-3-hydroxy- 5-methyl-4-isoxazole propionic acid (AMPA)-selective binding pharmacology (AMPA=quisqualate>glutamate>kainate) as well as cation channels gated by glutamate, AMPA, and kainate and blocked by 6,7-dinitroquinoxaline-2,3-dione (CNQX).

引用

页码：556 / 560

页数：5

共 47 条

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