1-HYDROXY-5,11-DIDEOXYTETRODOTOXIN, THE 1ST N-HYDROXY AND RING-DEOXY DERIVATIVE OF TETRODOTOXIN FOUND IN THE NEWT TARICHA-GRANULOSA

被引：60

作者：

KOTAKI, Y ^{[1
]}

SHIMIZU, Y ^{[1
]}

机构：

[1] UNIV RHODE ISL, COLL PHARM, DEPT PHARMACOGNOSY & ENVIRONM HLTH SCI, KINGSTON, RI 02881 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1993年 / 115卷 / 03期

关键词：

D O I：

10.1021/ja00056a001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new tetrodotoxin analogue, 1-hydroxy-5,11-dideoxytetrodotoxin, was isolated from the newt Taricha granulosa, and its structure was determined. It is the first example of an N-hydroxy and 5-deoxy derivative of tetrodotoxin found in nature, and its discovery may be highly significant with respect to the biosynthesis of tetrodotoxin and its toxigenesis in various tetrodotoxin-containing organisms.

引用

页码：827 / 830

页数：4

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