EXISTENCE OF A NOVEL HEMAGGLUTININ HAVING NO PROTEASE ACTIVITY IN VIBRIO-MIMICUS

被引：8

作者：

ALAM, M

MIYOSHI, S

MARUO, I

OGAWA, C

SHINODA, S

机构：

[1] Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Okayama 700

[2] Faculty of Pharmaceutical Sciences, Okayama University, Okayama

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1994年 / 38卷 / 06期

关键词：

VIBRIO MIMICUS; HEMAGGLUTININ; HA/PROTEASE;

D O I：

10.1111/j.1348-0421.1994.tb01809.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The protease elaborated by Vibrio mimicus is known to possess hemagglutinating ability to chicken erythrocytes, the well-known HA/protease. A non-protease hemagglutinin (HA) with strong agglutinating ability towards rabbit erythrocytes was obtained from 32 hr culture supernatant of a pathogenic environmental strain of V. mimicus. This HA (V. mimicus HA: VMHA) appeared stable at relatively higher temperature and agglutinated the erythrocytes from rabbit, guinea pig and mouse but not the erythrocytes from chicken, bovine, horse and sheep. Simple sugars, metal ions and chelating agents failed to inhibit the activity of VMHA. The activity of VMHA was found to be sensitive to digestion by proteolytic enzymes including HA/protease. These results provide evidence for the existence of novel HA other than HA/protease in V. mimicus.

引用

页码：467 / 470

页数：4

共 23 条

[1] PURIFICATION AND CHARACTERIZATION OF A NOVEL HEMAGGLUTININ FROM VIBRIO-CHOLERAE [J].