A HIGHLY EFFICIENT SYNTHESIS OF THE ANTHELMINTIC CYCLOOCTADEPSIPEPTIDE PF1022A

被引：28

作者：

SCHERKENBECK, J ^{[1
]}

PLANT, A ^{[1
]}

HARDER, A ^{[1
]}

MENCKE, N ^{[1
]}

机构：

[1] BAYER AG, BUSINESS GRP ANIM HLTH, D-51368 LEVERKUSEN, GERMANY

来源：

TETRAHEDRON | 1995年 / 51卷 / 31期

关键词：

D O I：

10.1016/0040-4020(95)00461-G

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The potent anthelmintic cyclooctadepsipeptide PF1022A was synthesized by a series of fragment condensations starting from the known (S)-2-chloropropanoic acid and (S)-2-chloro-3-phenylpropanoic acid in eleven steps with a total yield of 13%. Noteworthy is the excellent yield of the BOP-Cl mediated lactamization reaction of the linear precursor 17 leading to the 24-membered macrocycle.

引用

页码：8459 / 8470

页数：12

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