KINETICS OF INVITRO RELEASE OF SODIUM-SALICYLATE DISPERSED IN GELUCIRE

被引：18

作者：

BIDAH, D ^{[1
]}

VERGNAUD, JM ^{[1
]}

机构：

[1] UNIV ST ETIENNE, FAC SCI, MAT & CHEM ENGN LAB, 23 DR P MICHELON, F-42100 ST ETIENNE, FRANCE

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 58卷 / 03期

关键词：

Drug release; Gelucire; Kinetics; Sodium salicylate;

D O I：

10.1016/0378-5173(90)90198-D

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In order to obtain a controlled rate of delivery of sodium salicylate, spherical oral devices have been prepared and studied by using synthetic gastric liquid and in vitro tests. These devices have been prepared by dispersing the drug into Gelucire. The kinetics of release of drug has been found to be controlled by the erosion of Gelucire. The rate of drug delivery is then proportional to the actual area of the device, and a relationship between the time and the remaining weight of the device to the power one-third has been obtained. The effect of the (liquid volume)/(device weight) ratio on the rate of transfer has also been examined, and a decrease in this ratio provokes a decrease in the rate of transfer. © 1990.

引用

页码：215 / 220

页数：6

共 17 条

[1] MODELING OF DRUG RELEASE IN GASTRIC LIQUID FROM SPHERIC GALENIC FORMS WITH EUDRAGIT MATRIX [J].

ARMAND, JY ;

MAGNARD, F ;

BOUZON, J ;

ROLLET, J ;

TAVERDET, JL ;

VERGNAUD, JM .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 40 (1-2) :33-41

[2] DISSOLUTION OF A SOLUBLE DRUG SUBSTANCE FROM VINYL POLYMER MATRICES [J].

BROSSARD, C ;

DESYLOUSES, DL ;

DUCHENE, D ;

PUISIEUX, F ;

CARSTENSEN, JT .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1983, 72 (02) :162-169

[3]

DOELKER C, 1983, 3RD INT C PHARM TECH

[4] MODEL FOR MATTER TRANSFERS BETWEEN SODIUM SALICYLATE-EUDRAGIT MATRIX AND GASTRIC LIQUID [J].

DROIN, A ;

CHAUMAT, C ;

ROLLET, M ;

TAVERDET, JL ;

VERGNAUD, JM .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1985, 27 (2-3) :233-243

[5] SQUARE ROOT OF TIME-DEPENDENCE OF MATRIX FORMULATIONS WITH LOW DRUG CONTENT [J].

FESSI, H ;

MARTY, JP ;

PUISIEUX, F ;

CARSTENSEN, JT .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1982, 71 (07) :749-752

[6] CELLULOSIC MATERIALS - STRUCTURE AND ENZYMATIC-HYDROLYSIS RELATIONSHIPS [J].

FOCHER, B ;

MARZETTI, A ;

SARTO, V ;

BELTRAME, PL ;

CARNITI, P .

JOURNAL OF APPLIED POLYMER SCIENCE, 1984, 29 (11) :3329-3338

[7]

GATTEFOSSE, 1983, GELUCIRE LIQUID FORM

[8] MODELING OF SUSTAINED-RELEASE OF WATER-SOLUBLE DRUGS FROM POROUS, HYDROPHOBIC POLYMERS [J].

GURNY, R ;

DOELKER, E ;

PEPPAS, NA .

BIOMATERIALS, 1982, 3 (01) :27-32

[9]

Heller J, 1984, Crit Rev Ther Drug Carrier Syst, V1, P39

[10] ORAL POLYMER-DRUG DEVICES WITH A CORE AND AN ERODIBLE SHELL FOR CONSTANT DRUG DELIVERY [J].

LAGHOUEG, N ;

PAULET, J ;

TAVERDET, JL ;

VERGNAUD, JM .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1989, 50 (02) :133-139

← 1 2 →