MOLECULAR-CLONING OF CELL-ADHESION MOLECULE L1 FROM HUMAN NERVOUS-TISSUE - A COMPARISON OF THE PRIMARY SEQUENCES OF L1 MOLECULES OF DIFFERENT ORIGIN

被引：35

作者：

KOBAYASHI, M

MIURA, M

ASOU, H

UYEMURA, K

机构：

[1] Department of Physiology, Keio University School of Medicine, Tokyo

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1090卷 / 02期

关键词：

CELL ADHESION MOLECULE; L1; IMMUNOGLOBULIN SUPERFAMILY; CDNA CLONING; (HUMAN NEURON);

D O I：

10.1016/0167-4781(91)90108-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complementary DNA for the human neural cell adhesion molecule L1 was cloned and sequenced: the deduced amino acid sequence consists of 1257 amino acid residues containing six repeats of the immunoglobulin C2 domain and rive repeats of the fibronectin type III domain. The intracellular domain of human L1 is highly conserved as compared to mouse, but not identical to L1 cloned from human melanoma cells, suggesting the existence of alternative forms in the same species.

引用

页码：238 / 240

页数：3

共 8 条

[1] EXTENSION OF NEURITES ON AXONS IS IMPAIRED BY ANTIBODIES AGAINST SPECIFIC NEURAL CELL-SURFACE GLYCOPROTEINS [J].