EPITOPE MAPPING USING BACTERIOPHAGE PEPTIDE LIBRARIES

被引：47

作者：

LANE, DP

STEPHEN, CW

机构：

[1] University of Dundee, Dundee

来源：

CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 02期

关键词：

D O I：

10.1016/0952-7915(93)90016-L

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vast libraries of random peptides displayed on the surface of bacteriophage potentially allow identification of specific ligands for any peptide receptor of interest. The sequence specificity of antibody-peptide interactions allows these libraries to be used to define and localize continuous epitopes. Remarkably clear-cut results have been obtained with some antibodies; however, the technique has not proved to be generally applicable.

引用

收藏

页码：268 / 271

页数：4

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