LOCALIZATION OF THE HUMAN CD59 GENE BY FLUORESCENCE INSITU HYBRIDIZATION AND PULSED-FIELD GEL-ELECTROPHORESIS

被引：6

作者：

HECKLOSTREICHER, B

RAGG, S

DRECHSLER, M

SCHERTHAN, H

ROYERPOKORA, B

机构：

[1] UNIV HEIDELBERG,MED FAC MANNHEIM,INST PATHOL,W-6900 HEIDELBERG,GERMANY

[2] UNIV HEIDELBERG,INST HUMAN GENET & ANTHROPOL,W-6900 HEIDELBERG,GERMANY

来源：

CYTOGENETICS AND CELL GENETICS | 1993年 / 63卷 / 03期

关键词：

D O I：

10.1159/000133522

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have localized the human CD59 gene encoding a membrane protein that inhibits cell lysis by the membrane-attack complex of the homologous complement system. Using chromosomal in situ suppression hybridization and pulsed-field gel electrophoresis, we mapped this gene to chromosome 11p13, distal to the breakpoint of acute T-cell leukemia and proximal to the locus of the Wilms' tumor gene on a 30-kb SacII fragment.

引用

页码：144 / &

共 20 条

[1]

BRUNS G A P, 1984, American Journal of Human Genetics, V36, p25S

[2]

CHURCH GM, 1984, P NATL ACAD SCI USA, V81, P1911

[3] CD59, AN LY-6-LIKE PROTEIN EXPRESSED IN HUMAN LYMPHOID-CELLS, REGULATES THE ACTION OF THE COMPLEMENT MEMBRANE ATTACK COMPLEX ON HOMOLOGOUS CELLS [J].