RECOMBINANT HUMAN TUMOR-NECROSIS-FACTOR-ALPHA CONSTRICTS PIAL ARTERIOLES AND INCREASES BLOOD-BRAIN-BARRIER PERMEABILITY IN NEWBORN PIGLETS

被引：161

作者：

MEGYERI, P ^{[1
]}

ABRAHAM, CS ^{[1
]}

TEMESVARI, P ^{[1
]}

KOVACS, J ^{[1
]}

VAS, T ^{[1
]}

SPEER, CP ^{[1
]}

机构：

[1] UNIV GOTTINGEN, DEPT PEDIAT, W-3400 GOTTINGEN, GERMANY

来源：

NEUROSCIENCE LETTERS | 1992年 / 148卷 / 1-2期

基金：

匈牙利科学研究基金会;

关键词：

TUMOR NECROSIS FACTOR-ALPHA; BLOOD-BRAIN BARRIER; PIAL VASOREACTIVITY; CNS INFECTION; NEWBORN;

D O I：

10.1016/0304-3940(92)90823-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Tumor necrosis factor alpha (TNFalpha) plays a significant role in the pathogenesis of central nervous system infections. We investigated the effect of intracisternal injection of recombinant human TNFalpha (50-50,000 IU) on pial vasoreactivity and blood-brain barrier permeability in newborn piglets. The cytokine administration resulted in arterial vasoconstrictions, blood-brain barrier opening for Na-fluorescein (mol. wt. 376 Da) and increased Na-fluorescein uptake in brain regions examined (parietal and occipital cortex, cerebellum, pons/medulla, periventricular white matter) in a dose-dependent manner. TNFalpha may be involved in the pathophysiology of neonatal brain injuries.

引用

页码：137 / 140

页数：4

共 27 条

[1]

ABRAHAM CS, 1991, PEDIATR RES, V30, P648

[2]

ABRAHAM CS, 1991, PEDIATR RES COMMUN, V6, P1

[3] ANTI-EDRF EFFECT OF TUMOR NECROSIS FACTOR IN ISOLATED, PERFUSED CAT CAROTID ARTERIES [J].

AOKI, N ;

SIEGFRIED, M ;

LEFER, AM .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (05) :H1509-H1512

[4]

ARMSTEAD WM, 1988, CIRC RES, V62, P1, DOI 10.1161/01.RES.62.1.1

[5] BIDIRECTIONAL TRANSPORT OF INTERLEUKIN-1-ALPHA ACROSS THE BLOOD-BRAIN-BARRIER [J].

BANKS, WA ;

KASTIN, AJ ;

DURHAM, DA .

BRAIN RESEARCH BULLETIN, 1989, 23 (06) :433-437

[6] TUMOR NECROSIS FACTOR CACHECTIN INCREASES PERMEABILITY OF ENDOTHELIAL-CELL MONOLAYERS BY A MECHANISM INVOLVING REGULATORY G-PROTEINS [J].

BRETT, J ;

GERLACH, H ;

NAWROTH, P ;

STEINBERG, S ;

GODMAN, G ;

STERN, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (06) :1977-1991

[7] TUMOR-NECROSIS-FACTOR ALTERS CYTOSKELETAL ORGANIZATION AND BARRIER FUNCTION OF ENDOTHELIAL-CELLS [J].

CAMUSSI, G ;

TURELLO, E ;

BUSSOLINO, F ;

BAGLIONI, C .

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1991, 96 (01) :84-91

[8] TUMOR-NECROSIS-FACTOR (CACHECTIN) AS AN ESSENTIAL MEDIATOR IN MURINE CEREBRAL MALARIA [J].

GRAU, GE ;

FAJARDO, LF ;

PIGUET, PF ;

ALLET, B ;

LAMBERT, PH ;

VASSALLI, P .

SCIENCE, 1987, 237 (4819) :1210-1212

[9] ELEVATED ALPHA-TUMOR-NECROSIS-FACTOR LEVELS IN SPINAL-FLUID FROM HIV-1-INFECTED PATIENTS WITH CENTRAL-NERVOUS-SYSTEM INVOLVEMENT [J].

GRIMALDI, LME ;

MARTINO, GV ;

FRANCIOTTA, DM ;

BRUSTIA, R ;

CASTAGNA, A ;

PRISTERA, R ;

LAZZARIN, A .

ANNALS OF NEUROLOGY, 1991, 29 (01) :21-25

[10] TUMOR NECROSIS FACTOR IDENTIFIED IN MULTIPLE-SCLEROSIS BRAIN [J].

HOFMAN, FM ;

HINTON, DR ;

JOHNSON, K ;

MERRILL, JE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (02) :607-612

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