RAPID AND EFFICIENT ISOLATION OF THE NICOTINIC RECEPTOR ANTAGONIST METHYLLYCACONITINE FROM DELPHINIUM - ASSIGNMENT OF THE METHYLSUCCINIMIDE ABSOLUTE STEREOCHEMISTRY AS S

Methyllycaconitine (MLA) has been isolated from Garden Hybrid Delphinium and purified by vacuum liquid chromatography. C-13 NMR and optical rotation have been used to characterize the absolute configuration of the methylsuccinimide moiety as S. Ligand binding assays confirmed the potency of MLA and its selectivity for a-bungarotoxin-sensitive neuronal nicotinic acetylcholine receptors;