ON THE DNA RECOGNITION ROLE OF THE CARBOHYDRATE SECTOR IN CALICHEAMICIN - A COMPARISON OF DNA-CLEAVING CAPACITY OF ENANTIOMERIC CALICHEAMICINONES

被引：32

作者：

AIYAR, J ^{[1
]}

HITCHCOCK, SA ^{[1
]}

DENHART, D ^{[1
]}

LIU, KKC ^{[1
]}

DANISHEFSKY, SJ ^{[1
]}

CROTHERS, DM ^{[1
]}

机构：

[1] YALE UNIV,DEPT CHEM,NEW HAVEN,CT 06511

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1994年 / 33卷 / 08期

关键词：

D O I：

10.1002/anie.199408551

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Surprisingly, the “unnatural” aglycone analogue 1 (R  Ac) of calicheamicin cleaves double‐stranded DNA more effectively than the natural ent‐1. If the efficiency of this cleavage for the enediyne effector is determined essentially by its configuration, the sequence selectivity of calicheamicin is rooted in the saccharide recognition sector. (Figure Presented.) Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany

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页码：855 / 858

页数：4

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