NMDA-INDUCED RHYTHMICAL ACTIVITY IN XII-NERVE OF ISOLATED CNS FROM NEWBORN RATS

被引：29

作者：

KATAKURA, N

JIA, L

NAKAMURA, Y

机构：

[1] Department of Physiology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113

来源：

NEUROREPORT | 1995年 / 6卷 / 04期

关键词：

RHYTHM; EXCITATORY AMINE ACID; NMDA; IN VITRO PREPARATION; BRAIN STEM SPINAL CORD; HYPOGLOSSUS; OROFACIAL STRUCTURE;

D O I：

10.1097/00001756-199503000-00004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE tried to induce rhythmical ore-facial motor activities in an isolated brain stem-spinal cord preparation from newborn rats. Neural activities were monitored from the hypoglossal nerve (XII N) and the ventral roots of the cervical cord. Bath application of N-methyl-D-aspartate (NMDA) as well as glutamate induced rhythmical burst activity in XII N distinct from and much faster than respiratory rhythm. This NMDA-induced rhythmical activity was blocked by simultaneous application of 2-amino-5-phosphonovalerate (AP5). The results demonstrate that NMDA receptor activation can induce rhythmical XII N activity different from respiration in an isolated mammalian CNS. This preparation will be useful for the investigation of neural mechanisms underlying the central generation of food ingestive movements.

引用

页码：601 / 604

页数：4

共 24 条

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