INHIBITION OF COCAINE SENSITIZATION BY MK-801, A NONCOMPETITIVE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ANTAGONIST - EVALUATION BY AMBULATORY ACTIVITY IN MICE

被引:39
作者
IDA, I
ASAMI, T
KURIBARA, H
机构
[1] GUNMA PREFECTURAL SAWA HOSP PSYCHIAT,GUNMA 37922,JAPAN
[2] GUNMA UNIV,SCH MED,BEHAV RES INST,DEPT NEUROBIOL & BEHAV,MAEBASHI,GUMMA 371,JAPAN
关键词
MK-801; AMBULATORY ACTIVITY; REPEATED ADMINISTRATION; COCAINE SENSITIZATION; DRUG INTERACTION;
D O I
10.1254/jjp.69.83
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Alterations of cocaine effects, which were induced by prior repeated 5-time administration of MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo-5H-dibenzo[a,d]cyclohepten-5,10-imine) (i.p.) alone or in combination with cocaine (s.c.) at 3- to 4-day intervals, were investigated by means of ambulatory activity in mice. The repeated administration of either cocaine (10 and 20 mg/kg) alone or MK-801 (0.3 mg/kg) alone progressively enhanced each drug's effect. The enhanced effects of cocaine and MK-801 were estimated to be 1.8-2.2 times and about 1.4 times, respectively, as great as those at the Ist administration. Although the coadministration of MK-801 with cocaine produced a significant enhancement in the ambulation-increasing effect, the comparatively higher doses of MK-801 (0.3 and 1 mg/kg) acted not only to reduce cocaine sensitivity but also to inhibit the development of cocaine sensitization. Thus, the mice that had been given MK-801 (0.3 and 1 mg/kg) alone 5 times showed lower sensitivities to cocaine (20 mg/kg) than the mice given saline alone. The mice coadministered MK-801 (0.3 and 1 mg/kg) with cocaine (10 and 20 mg/kg) also exhibited lower sensitivities to cocaine(10 and 20 mg/kg) than those given cocaine alone. However, MK-801 could not ameliorate the established sensitization to cocaine. Similar interactions have been demonstrated between MK-801 at 1 mg/kg, but not 0.3 mg/kg, and methamphetamine. The present results indicate that MK-801 can inhibit the development of sensitization to cocaine at a lower dose than that required to inhibit methamphetamine sensitization.
引用
收藏
页码:83 / 90
页数:8
相关论文
共 19 条
  • [1] Wong E.H.F., Kemp J.A., Priestley T., Knight A.R., Woodruff G.N., Iversen L.L., The anticonvulsant MK-801 is a potent N-methyl-d-aspartate antagonist, Proc Natl Acad Sci USA, 83, pp. 7104-7108, (1986)
  • [2] Foster A.C., Wong E.H.F., The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-d-aspartate receptor in rat brain, Br J Pharmacol, 91, pp. 403-409, (1987)
  • [3] Simon R.P., Swan J.H., Griffiths T.D., Meldrum B.S., Blockade of N-methyl-d-aspartate receptors may protect against ischemic damage in the brain, Science, 226, pp. 850-852, (1984)
  • [4] Wieloch T., Hypoglycemia-induced neuronal damage prevented by an N-methyl-d-aspartate antagonist, Science, 230, pp. 681-683, (1985)
  • [5] Clineschmidt B.V., Williams M., Witoslawski J.J., Bunting P.R., Risley E.A., Totaro J.A., Restoration of shock-suppressed behavior by treatment with (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), a substance with potent anticonvulsant, central sympathomimetic and apparent anxiolytic properties, Drug Dev Res, 2, pp. 147-163, (1982)
  • [6] Kuribara H., Fujiwara S., Yasuda H., Tadokoro S., The anti-conflict effect of MK-801, an NMDA antagonist: Investigation by punishment procedure in mice, Jpn J Pharmacol, 54, pp. 250-252, (1990)
  • [7] Clineschmidt B.V., Martin G.E., Bunting P.R., Papp N.L., Central sympathomimetic activity of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), a substance with potent anticonvulsant, central sympathomimetic and apparent anxiolytic properties, Drug Dev Res, 2, pp. 135-145, (1982)
  • [8] Kuribara H., Asami T., Ida I., Tadokoro S., Characteristics of the ambulation-increasing effect of the noncompetitive NMDA antagonist MK-801 in mice: Assessment by the coadministration with central-acting drugs, Jpn J Pharmacol, 58, pp. 11-18, (1992)
  • [9] Choi D.W., Glutamate neurotoxicity and disease of the nervous system, Neuron, 1, pp. 623-634, (1988)
  • [10] Robinson T., Becker J., Enduring change in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis, Brain Res Rev, 11, pp. 157-198, (1986)