DISPOSITION KINETICS AND ORAL BIOAVAILABILITY OF VINCAMINE-LOADED POLYALKYL CYANOACRYLATE NANOPARTICLES

Hexyl cyanoacrylate nanoparticles loaded with vincamine as a drug model were prepared. Disposition kinetics and oral bioavailability of vincamine in rabbits were compared after administration of an aqueous solution of the drug and an aqueous colloidal suspension of nanoparticles. After intravenous administration, total body clearance of vincamine was equal for both dosage forms, but a longer half-life (.times. 2) and larger distribution volume (.times. 2) were observed with the suspension of nanoparticles. After oral administration, the bioavailability of vincamine was considerably greater for the drug loaded onto nanoparticles.