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PROTON MAGNETIC-RESONANCE SPECTROSCOPY OF HUMAN BRAIN INVIVO IN THE EVALUATION OF MULTIPLE-SCLEROSIS - ASSESSMENT OF THE LOAD OF DISEASE

被引：257
作者：
ARNOLD, DL
MATTHEWS, PM
FRANCIS, G
ANTEL, J
机构：
[1] Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec
来源：
MAGNETIC RESONANCE IN MEDICINE | 1990年 / 14卷 / 01期
关键词：
D O I：
10.1002/mrm.1910140115
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 [临床医学]; 100207 [影像医学与核医学]; 1009 [特种医学];
摘要：
Image localized, water‐suppressed proton magnetic resonance spectra were obtained from affected brain in patients with multiple sclerosis. In patients with moderate to severe chronic disease, spectra revealed a decreased ratio of N‐acetylaspartate to creatine resonance intensities. A normal ratio was obtained from a large recently symptomatic MRI plaque that resolved without sequelae. We propose that the observed metabolite changes can be useful as an index of irreversible CNS injury. © 1990 Academic Press, Inc. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
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收藏
页码：154 / 159
页数：6
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