TYROSINE LOADING INCREASES DOPAMINE METABOLITE CONCENTRATIONS IN THE BRAIN

被引：9

作者：

CHANCE, WT ^{[1
]}

FOLEYNELSON, T ^{[1
]}

NELSON, JL ^{[1
]}

FISCHER, JE ^{[1
]}

机构：

[1] VET AFFAIRS MED CTR,CINCINNATI,OH

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 35卷 / 01期

关键词：

Amino acid; DOPAC; Dopamine; HVA; Neurotransmitter; Rat; Tyrosine;

D O I：

10.1016/0091-3057(90)90226-8

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Administration of haloperidol (1.5 mg/kg) to rats increased concentrations of dopamine metabolites in the corpus striatum, nucleus accumbens, hypothalamus and amygdala. Treatment of similar rats with various doses (25, 100 or 400 mg/kg) of tyrosine methyl ester in combination with the haloperidol led to additional elevations of 3,4-dihydroxyphenylacetic acid (DOPAC) in the corpus striatum and hypothalamus at the lowest dose tested. Therefore, it is concluded that during periods of increased neuronal activity, as induced by haloperidol, tyrosine availability may become a rate-limiting factor in dopamine metabolism. © 1990.

引用

页码：195 / 199

页数：5

共 24 条

[1] ENHANCEMENT OF RAT-BRAIN CATECHOLAMINE SYNTHESIS BY ADMINISTRATION OF SMALL DOSES OF TYROSINE AND EVIDENCE FOR SUBSTRATE-INHIBITION OF TYROSINE-HYDROXYLASE ACTIVITY BY LARGE DOSES OF THE AMINO-ACID [J].