MALE ANTIGEN DEFINED SEROLOGICALLY DOES NOT IDENTIFY A FACTOR RESPONSIBLE FOR TESTICULAR DEVELOPMENT

被引：15

作者：

GOLDBERG, EH ^{[1
]}

MCLAREN, A ^{[1
]}

REILLY, B ^{[1
]}

机构：

[1] UNIV LONDON UNIV COLL,MRC,MAMMALIAN DEV UNIT,LONDON NW1 2HE,ENGLAND

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1991年 / 20卷 / 03期

关键词：

XXSXR' MALE MICE; SEROLOGICALLY DETECTED MALE ANTIGEN (SDMA);

D O I：

10.1016/0165-0378(91)90055-U

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To test the proposal that the serologically detected male antigen (SDMA; which may or may not be the same as H-Y) was responsible for triggering the indifferent gonad to differentiate into the testis in mammals, H-Y negative sex-reversed XXSxr' male mice were investigated for the presence of SDMA. Serum from C57BL/6 female mice immunized against tissue from XXSxr' males did not contain SDMA specific antibody as detected by the complement-mediated sperm cytotoxicity assay. Thus, although SDMA is a male-specific factor and may play a role in male sex determination, it does not identify the testis-determining factor (TDF).

引用

页码：305 / 309

页数：5

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