ALTERATIONS OF A ZINC-FINGER ENCODING GENE, BCL-6, IN DIFFUSE LARGE-CELL LYMPHOMA

被引：614

作者：

YE, BH

LISTA, F

LOCOCO, F

KNOWLES, DM

OFFIT, K

CHAGANTI, RSK

DALLAFAVERA, R

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT PATHOL,NEW YORK,NY 10032

[2] MEM SLOAN KETTERING CANC CTR,CELL BIOL & GENET PROGRAM,NEW YORK,NY 10021

[3] MEM SLOAN KETTERING CANC CTR,DEPT PATHOL,NEW YORK,NY 10021

[4] CTR STUDI & RIC SANITA ESERCITO,ROME,ITALY

[5] UNIV ROMA LA SAPIENZA,DIPARTIMENTO BIOPATOL UMANA,SEZ EMATOL,I-00185 ROME,ITALY

来源：

SCIENCE | 1993年 / 262卷 / 5134期

关键词：

D O I：

10.1126/science.8235596

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type of lymphoma, is unknown. A gene was cloned from chromosomal translocations affecting band 3q27, which are common in DLCL. This gene, BCL-6, codes for a 79-kilodalton protein that is homologous with zinc finger-transcription factors. In 33 percent (13 of 39) of DLCL samples, but not in other types of lymphoid malignancies, the BCL-6 gene is truncated within its 5' noncoding sequences, suggesting that its expression is deregulated. Thus, BCL-6 may be a proto-oncogene specifically involved in the pathogenesis of DLCL.

引用

页码：747 / 750

页数：4

共 48 条

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