EFFECT OF CARBACHOL ON LUMINAL RELEASE OF SOMATOSTATIN FROM ISOLATED PERFUSED RAT DUODENUM

被引：17

作者：

FUJIMIYA, M

MCINTOSH, CHS

KIMURA, H

KWOK, YN

机构：

[1] UNIV BRITISH COLUMBIA,DEPT PHYSIOL,MRC,REGULATORY PEPTIDE GRP,VANCOUVER V6T 1W5,BC,CANADA

[2] SHIGA UNIV MED SCI,INST MOLEC NEUROBIOL,OTSU,SHIGA 52021,JAPAN

来源：

NEUROSCIENCE LETTERS | 1992年 / 145卷 / 02期

关键词：

RAT DUODENUM; SOMATOSTATIN-LIKE IMMUNOREACTIVITY; LUMINAL RELEASE; SOMATOSTATIN-28; SOMATOSTATIN-14; CARBACHOL;

D O I：

10.1016/0304-3940(92)90029-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The dynamic release of somatostatin-like immunoreactivity (SLI) from duodenum into the lumen was studied in the isolated, vascularly perfused rat duodenum. The luminal release of duodenal SLI was stimulated by a cholinergic agonist, carbachol, and the carbachol-induced release of SLI was completely blocked by atropine, but not by hexamethonium. These data suggest that the luminal release of SLI from rat duodenum is under the control of a cholinergic muscarinic stimulation. The ratio of somatostatin- 14 to somatostatin-28 in picograms was about 1 during basal release but increased to approximately 2 during carbachol stimulation.

引用

页码：229 / 233

页数：5

共 23 条

[1] ON THE INTERACTION BETWEEN INTRAGASTRIC PH AND ELECTRICAL VAGAL-STIMULATION IN CAUSING GASTRIC-ACID SECRETION AND INTRALUMINAL RELEASE OF GASTRIN AND SOMATOSTATIN IN ANESTHETIZED RATS [J].