COMPARISON OF CHIRAL SEPARATIONS IN CAPILLARY ZONE ELECTROPHORESIS WITH OTHER METHODS

被引:14
作者
ISSAQ, HJ
机构
[1] Program Resources, Inc./DynCorp, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland, 21702, P.O. Box B
关键词
D O I
10.1080/10739149408001183
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Capillary zone electrophoresis (CZE) is an efficient microseparation technique that can be used for the separation of small as well as large biomolecules. The use of micelles in the buffer makes CZE an acceptable technique for the resolution of charged and neutral molecules. The separation of chiral compounds is an important aspect of the pharmaceutical industry, synthetic organic chemistry and other areas. Optical isomers can be separated from each other using high pressure liquid chromatography (HPLC) and capillary gas chromatography (CGC), however, each of these techniques has its limitations. CGC and HPLC require a chiral column, which is costly, CZE does not. CZE has the highest efficiency and chiral separations are achieved by adding a modifier to the buffer that facilitates the separation of optical isomers. In this review the advantages and disadvantages of HPLC, CGC and CZE for chiral separations will be discussed.
引用
收藏
页码:119 / 149
页数:31
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