THE RECOGNITION OF 3 DIFFERENT EPITOPES FOR THE H-TYPE-2 HUMAN BLOOD-GROUP DETERMINANT BY LECTINS OF ULEX-EUROPAEUS, GALACTIA-TENUIFLORA AND PSOPHOCARPUS-TETRAGONOLOBUS (WINGED BEAN) .15.

被引：40

作者：

DU, MH ^{[1
]}

SPOHR, U ^{[1
]}

LEMIEUX, RU ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT CHEM,EDMONTON T6G 2G2,AB,CANADA

来源：

GLYCOCONJUGATE JOURNAL | 1994年 / 11卷 / 05期

关键词：

LECTIN SPECIFICITIES; H-TYPE 2 BLOOD GROUP DETERMINANT; CHEMICAL MAPPING OF EPITOPES; LECTINS OF ULEX EUROPAEUS; GALACTIA TENUIFLORA AND PSOPHOCARPUS TETRAGONOLOBUS;

D O I：

10.1007/BF00731281

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chemical mapping of the regions of H-type 2 human blood group-related trisaccharide (Fuc alpha(1-2)Gal beta(1-4)GlcNA beta Me) that are recognized by three different lectins, the so-called epitopes, are reviewed together with an account of how and why oligosaccharides form specific complexes with proteins as presently viewed in this laboratory. The occasion is used to report the synthesis of the various mono-O-methyl derivatives of the above trisaccharide that were used in these investigations. Also, Fuc alpha(1-2)Gal beta(1-4)Xyl beta Me was synthesized in order to examine whether or not the hydroxymethyl group of the GlcNAc residue participates in the binding reaction.

引用

页码：443 / 461

页数：19

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