COMPARATIVE INVITRO ACTIVITIES OF NORFLOXACIN (MK-0366) AND 6 COMMONLY USED ANTIMICROBIAL AGENTS AGAINST 199 URINARY ISOLATES SHOWING VARIOUS DEGREES OF ANTIBIOTIC-RESISTANCE
被引:6
作者:
CORIGLIANO, BE
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UNIV SO CALIF, LOS ANGELES CTY MED CTR, DEPT MED, LOS ANGELES, CA 90033 USAUNIV SO CALIF, LOS ANGELES CTY MED CTR, DEPT MED, LOS ANGELES, CA 90033 USA
CORIGLIANO, BE
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APPLEMAN, MD
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UNIV SO CALIF, LOS ANGELES CTY MED CTR, DEPT MED, LOS ANGELES, CA 90033 USAUNIV SO CALIF, LOS ANGELES CTY MED CTR, DEPT MED, LOS ANGELES, CA 90033 USA
APPLEMAN, MD
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HESELTINE, PNR
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UNIV SO CALIF, LOS ANGELES CTY MED CTR, DEPT MED, LOS ANGELES, CA 90033 USAUNIV SO CALIF, LOS ANGELES CTY MED CTR, DEPT MED, LOS ANGELES, CA 90033 USA
HESELTINE, PNR
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LEEDOM, JM
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UNIV SO CALIF, LOS ANGELES CTY MED CTR, DEPT MED, LOS ANGELES, CA 90033 USAUNIV SO CALIF, LOS ANGELES CTY MED CTR, DEPT MED, LOS ANGELES, CA 90033 USA
LEEDOM, JM
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机构:
[1] UNIV SO CALIF, LOS ANGELES CTY MED CTR, DEPT MED, LOS ANGELES, CA 90033 USA
The in vitro activity of norfloxacin (MK-0366), a new oral antimicrobial agent, was compared to that of ampicillin, tetracycline, cefazolin, nitrofurantoin, nalidixic acid and trimethoprim against 199 gram-negative urinary isolates. Among these isolates were ampicillin-resistant Escherichia coli and gentamicin-resistant Pseudomonas aeruginosa and Serratia marcescens. Norfloxacin was the most active antimicrobial agent tested against all isolates studied; it was the only agent active against P. aeruginosa and S. marcescens.