NUCLEAR INOSITOL LIPIDS IN FRIEND-ERYTHROLEUKEMIA CELLS - CHANGES RELATED TO DIFFERENTIATION INDUCED BY HEXAMETHYLENEBISACETAMIDE

被引：19

作者：

CAPITANI, S ^{[1
]}

MAZZONI, M ^{[1
]}

BERTAGNOLO, V ^{[1
]}

PREVIATI, M ^{[1
]}

DADDONA, A ^{[1
]}

RICCI, D ^{[1
]}

MANZOLI, FA ^{[1
]}

机构：

[1] UNIV BOLOGNA,INST HUMAN ANAT,I-40126 BOLOGNA,ITALY

来源：

CELL BIOLOGY INTERNATIONAL REPORTS | 1990年 / 14卷 / 09期

关键词：

D O I：

10.1016/0309-1651(90)90005-J

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Subcellular distribution of inositol lipids has been stu died in Friend Erythroleukemia Cells following induction to erythroid differentiation with hexamethylenebisacetamide, after labelling with [3H]myo-inositol. In situ autoradiography indicated that inositol-derived molecules were present also in the nuclear compartment of uninduced and induced cells. Fractionation studies showed that the nuclear polyphosphoinositides were deeply changed after short induction times, while the whole cell inositol lipids resulted only slightly modified by the inducer. The nuclear recovery of phosphatidylinositol 4,5-bisphosphate was largely increased after 2 hrs of induction, sugge sting that inositol lipid metabolism is involved in the early differentiation events occurring at the nuclear level. © 1990.

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页码：783 / 795

页数：13

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