ORGANIC-SYNTHESIS USING HALOBORATION REACTION .21. A SYNTHESIS OF PROSTAGLANDIN B-1 METHYL-ESTER BY THE STEPWISE CROSS-COUPLING REACTION USING (E)-(2-BROMOETHENYL)DIISOPROPOXYBORANE

被引：12

作者：

HYUGA, S ^{[1
]}

HARA, S ^{[1
]}

SUZUKI, A ^{[1
]}

机构：

[1] HOKKAIDO UNIV, FAC ENGN, DEPT APPL CHEM, SAPPORO, HOKKAIDO 060, JAPAN

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1992年 / 65卷 / 08期

关键词：

D O I：

10.1246/bcsj.65.2303

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A prostaglandin B1(PGB1) analog and PGB1 methyl ester were synthesized by the palladium-catalyzed stepwise cross-coupling reaction of (E)-(2-bromoethenyl)diisopropoxyborane with (1-methoxy-l-hexenyl)zinc chloride and 3-bromo-2-cyclopenten-1-one derivatives. According to this method, the skeleton of PGB1 is prepared by the one-pot operation without isolation of any intermediates.

引用

页码：2303 / 2305

页数：3

共 12 条

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