PREPARATION OF (4S)-4-HYDROXY-3-METHYL-2-(2'-PROPYNYL)-2-CYCLOPENTENONE BY COMBINATION OF ENZYMATIC-HYDROLYSIS AND CHEMICAL TRANSFORMATION

被引：18

作者：

DANDA, H

MAEHARA, A

UMEMURA, T

机构：

[1] Takarazuka Research Center, Sumitomo Chemical Co., Ltd., Takarazuka, Hyogo, 665, 2-1, 4-Chome, Takatsukasa

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(00)93443-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(4S)-4-Hydroxy-3-methyl-2-(2'-propynyl)-2-cyclopentenone ((S)-2), which is an important alcohol moiety of optically active pyrethroid insecticides, was prepared from the corresponding racemic acetate ((+/-)-1) by the combination of enzymatic hydrolysis and chemical transformation in high chemical and optical yields.

引用

页码：5119 / 5122

页数：4

共 4 条

[1] SYNTHESES OF DIASTEREOISOMERS OF RECENT PYRETHROIDS, FENVALERATE (S-5602) AND CYPERMETHRIN (NRDC-149) FROM (-)-3-PHENOXY-MANDELIC ACID AND DETERMINATION OF THEIR ABSOLUTE-CONFIGURATIONS [J].