ORGANUM VASCULOSUM LAMINAE TERMINALIS (OVLT) IS A BRAIN SITE TO PRODUCE INTERLEUKIN-1-BETA DURING FEVER

被引：40

作者：

NAKAMORI, T ^{[1
]}

MORIMOTO, A ^{[1
]}

YAMAGUCHI, K ^{[1
]}

WATANABE, T ^{[1
]}

LONG, NC ^{[1
]}

MURAKAMI, N ^{[1
]}

机构：

[1] YAMAGUCHI UNIV, SCH MED, INST LAB ANIM, UBE, YAMAGUCHI 755, JAPAN

来源：

BRAIN RESEARCH | 1993年 / 618卷 / 01期

关键词：

ENDOTOXIN; INTERLEUKIN-1-BETA; ORGANUM VASCULOSUM LAMINAE TERMINALIS; FEVER AND IN-SITU HYBRIDIZATION;

D O I：

10.1016/0006-8993(93)90439-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study was carried out to determine whether interleukin-1 (IL-1) production occurs in the rabbit organum vasculosum laminae terminalis (OVLT) during fever induced by endotoxin. The intravenous (i.v.) injection of endotoxin (4 mug/kg) caused significant fever in rabbits. Through the use of in situ hybridization and immunohistochemical techniques, the synthesis of IL-1 was observed in the OVLT during the fever. The present results support the hypothesis that IL-1 is produced in the brain during fever.

引用

页码：155 / 159

页数：5

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