PHARMACOKINETICS AND SUCTION BLISTER FLUID PENETRATION OF A SEMISYNTHETIC INJECTABLE STREPTOGRAMIN RP-59500 (RP-57669 RP-54476)

被引：11

作者：

BERNARD, E ^{[1
]}

BENSOUSSAN, M ^{[1
]}

BENSOUSSAN, F ^{[1
]}

ETIENNE, S ^{[1
]}

CAZENAVE, I ^{[1
]}

CARSENTIETESSE, E ^{[1
]}

LEROUX, Y ^{[1
]}

MONTAY, G ^{[1
]}

DELLAMONICA, P ^{[1
]}

机构：

[1] RHONE POULENC RORER,F-92165 ANTONY,FRANCE

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1994年 / 13卷 / 09期

关键词：

D O I：

10.1007/BF02276064

中图分类号：

R51 [传染病];

学科分类号：

100401 [流行病与卫生统计学];

摘要：

RP 59500 is a new semisynthetic injectable streptogramin with excellent activity against most gram-positive bacteria. In order to assess its potential for the treatment of tissue infections, the pharmacokinetics and penetration into suction blister fluid were studied in a pilot phase I study in six male volunteers following a single infusion of 12 mg/kg over 1 h. Plasma and suction blister fluid concentrations were determined by microbiological assay. The mean peak concentration in plasma was 8.65 mg/l at the end of infusion. The mean plasma elimination half-life was 1.48 h. The mean peak concentration in interstitial fluid was 2.41 mg/l and was reached after Ih in two volunteers and after 2 h in the other four. The mean percentage penetration for the interval 0-6 h was 82.5 %. RP 59500 was still detectable in interstitial fluid at 6 h at a mean concentration of 0.92 +/- 0.25 mg/l. The data of this pilot study demonstrate good penetration of RP 59500 into non-inflammatory interstitial fluid.

引用

页码：768 / 771

页数：4

共 11 条

[1]

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[2]

BERGAN T, 1981, REV INFECT DIS, V3, P45

[3]

INVITRO AND INVIVO SYNERGIC ACTIVITY AND FRACTIONAL INHIBITORY CONCENTRATION (FIC) OF THE COMPONENTS OF A SEMISYNTHETIC STREPTOGRAMIN, RP 59500 [J].