WIDESPREAD ALTERATIONS IN CENTRAL NORADRENALINE, DOPAMINE, AND SEROTONIN SYSTEMS IN THE BRATTLEBORO RAT NOT RELATED TO THE LOCAL ABSENCE OF VASOPRESSIN

被引:21
作者
FEENSTRA, MGP
SNIJDEWINT, FGM
VANGALEN, H
BOER, GJ
机构
[1] Netherlands Institute for Brain Research, Amsterdam Z.O., 1105 AZ
关键词
D O I
10.1007/BF00968673
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A comprehensive study of monoamine transmitter and metabolite concentrations measured by HPLC was undertaken in female (vasopressin-deficient) Brattleboro rats as compared to Long Evans rats. Noradrenaline was significantly increased in 8 out of 13 dissected brain regions, whereas concentrations of the metabolite 3-methoxy-4-hydroxyphenylglycol were not altered. The increases were not restricted to areas which are normally innervated by vasopressin-containing neurons. Serotonin was increased in 6 and dopamine in 4 regions and this was accompanied in some areas by increases in the metabolites 5-hydroxyindolacetic acid and dihydroxyphenylacetic acid. Only in the striatum, cerebellum, and the medulla-pons no changes could be detected in any of the compounds of interest. These results show that the long term absence of vasopressin in Brattleboro rats appears to be associated with increases in monoamine transmitter contents and decreased metabolite/transmitter ratios. The regional distribution of these changes does not bear any relationship to the regional distribution of vasopressin cell bodies or nerve endings. © 1990 Plenum Publishing Corporation.
引用
收藏
页码:283 / 288
页数:6
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