In order to extend our earlier work on in-situ off-axis sputtering to larger areas, we have used two facing targets in the off-axis configuration to produce YBa2Cu3O7-delta superconducting films with low microwave surface resistance on 5 cm diameter LaAlO3 substrates. Surface resistance (Rs) values at 10 GHz of 40+/-10-mu-OMEGA at 4.2 K and 400+/-100-mu-OMEGA at 77 K, superconducting transition temperatures of over 89 K and thickness variations of less than +/-8% are uniformally obtained over the entire 5 cm diameter area. We also report a detailed characterization of the electronic and structural properties of the films produced on the LaAlO3 substrates for a wide range of growth conditions. The role of YBCO microstructure on the transport properties and the effect of magnet geometry in the two sputter guns will also be discussed.