CARCINOGENICITY OF 2-AMINO-3-METHYLIMIDAZO[4,5-F]QUINOLINE IN NONHUMAN-PRIMATES - INDUCTION OF TUMORS IN 3 MACAQUES

被引：264

作者：

ADAMSON, RH

THORGEIRSSON, UP

SNYDERWINE, EG

THORGEIRSSON, SS

REEVES, J

DALGARD, DW

TAKAYAMA, S

SUGIMURA, T

机构：

[1] NATL CANC CTR,RES INST,CHUO KU,TOKYO 104,JAPAN

[2] HAZELTON LABS AMER INC,VIENNA,VA 22180

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1990年 / 81卷 / 01期

关键词：

Hepatocellular carcinoma; Heterocyclic amines; Nonhuman primates;

D O I：

10.1111/j.1349-7006.1990.tb02500.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The carcinogenic potential of 2‐amino‐3‐methylimidazo[4,5f]quinoline (IQ) was evaluated in cynomolgus monkeys. Monkeys received IQ, beginning at the age of one year, at doses of 10 or 20 mg/kg by gavage. Thus far, IQ has induced hepatocellular carcinoma in three monkeys with a latent period of 27 to 37 months. Metastases to the lung occurred in two of the three monkeys. Microscopically, the hepatocellular carcinoma in all three cases demonstrated a trabecular pattern. These data demonstrate that IQ is a potent carcinogen in nonhuman primates and support the idea that it is a potential carcinogen for humans. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：10 / 14

页数：5

共 7 条

[1]

Adamson R H, 1983, Basic Life Sci, V24, P129

[2] CARCINOGENICITY OF 1-METHYL-1-NITROSOUREA IN NONHUMAN-PRIMATES [J].

ADAMSON, RH ;

KROLIKOWSKI, FJ ;

CORREA, P ;

SIEBER, SM ;

DALGARD, DW .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1977, 59 (02) :415-422

[3]

ADAMSON RH, 1982, MALIGNANT LYMPHOMAS, P239

[4]

ADAMSON RH, 1979, REGULATORY ASPECTS C, P275

[5] CARCINOGENICITY IN MICE OF A MUTAGENIC COMPOUND, 2-AMINO-3-METHYLIMIDAZO[4,5-F]QUINOLINE, FROM BROILED SARDINE, COOKED BEEF AND BEEF EXTRACT [J].

OHGAKI, H ;

KUSAMA, K ;

MATSUKURA, N ;

MORINO, K ;

HASEGAWA, H ;

SATO, S ;

TAKAYAMA, S ;

SUGIMURA, T .

CARCINOGENESIS, 1984, 5 (07) :921-924

[6] CARCINOGENICITY OF MUTAGENIC HETEROCYCLIC AMINES FORMED DURING THE COOKING PROCESS [J].

SUGIMURA, T .

MUTATION RESEARCH, 1985, 150 (1-2) :33-41

[7]

TAKAYAMA S, 1984, JPN J CANCER RES, V75, P467

← 1 →