HYDROXYL RADICAL SCAVENGING AND ANTIPSORIATIC ACTIVITY OF BENZOIC-ACID DERIVATIVES

被引：39

作者：

HASELOFF, RF

BLASIG, IE

MEFFERT, H

EBERT, B

机构：

[1] Academy of Sciences, the GDR, Central Institute of Molecular Biology, Berlin, 1115

[2] Academy of Sciences, the GDR, Institute of Drug Research, Berlin

[3] Humboldt University, School of Medicine (Charité), Berlin

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 9卷 / 02期

关键词：

Antipsoriatic activity; Benzoic acid derivatives; ESR; Free radicals; Hydroxyl radical scavenging activity; Spin Trapping;

D O I：

10.1016/0891-5849(90)90113-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hydroxyl radical scavenging and antipsoriatic activity of a number of lipophilic and hydrophilic benzoic acid derivatives was investigated. To quantify antioxidative effects, a newly introduced test system based on the diminution of the ESR signal of DMPO-OH (generated by Fenton's reagent) by the tested compounds was applied. It was found that the in vitro antioxidative (toward hydroxyl radical) activity of benzoic acid esters decreases with increasing chain length whereas the antisoriatic activity increases. This effect is discussed in terms of a larger lipophilicity of long-chain esters. Propyl gallate was found to be the most active ȮH scavenger since it is some orders of magnitude more efficient than "model" antioxidants like α-tocopherol or mannitol. The highest antipsoriatic activity was exhibited by hydroxy benzoic acid decyl ester. © 1990.

引用

页码：111 / 115

页数：5

共 15 条

[1]

Flohe, Loschen, The therapeutical mechanism of action of exogenous superoxide dismutase: results and prospects, Eur. J. Rheumatol. Inflamm., 4, pp. 183-200, (1981)

[2]

Blasig, Ebert, Loewe, Identification of free radicals trapped during myocardial ischemia in vitro by ESR, stud. biophys., 116, pp. 35-42, (1986)

[3]

Blasig, Loewe, Ebert, Radical trapping and lipid peroxidation during myocardial reperfusion injury—radical scavenging by troxeturin in comparison to mannitol, Biomed. Biochim. Acta, 46, pp. 539-544, (1987)

[4]

Singh, Singh, Time-scale and nature of radiation-biological damage: approaches to radiation protection and post-irradiation therapy, Prog. Biophys. Mol. Biol., 39, pp. 69-107, (1982)

[5]

Haseloff, Ebert, Roeder, Generation of free radicals by photoexcitation of pheophorbide a, haematoporphyrin and protoporphyrin, J. Photochem. Photobiol. B: Biol., 3, pp. 593-602, (1989)

[6]

Lands, Kulmacz, The regulation of the biosynthesis of prostaglandins and leukotrienes, Prog. Lipid Res., 25, pp. 105-109, (1986)

[7]

Cheung, Lark, Robinson, Pomery, Hunter, The production of hydroxyl radical by human neutrophils stimulated by arachidonic acid—measurements by ESR spectroscopy, Aust. J. Exp. Biol. Med. Sci., 64, pp. 157-164, (1986)

[8]

Brain, Camp, Dowd, Psoriasis and leukotriene B<sub>4</sub>, The Lancet, pp. 762-763, (1982)

[9]

Miehe, Meffert, Bewertung potentieller Antipsoriatika, Dermatol. Monatsschr., 170, pp. 32-33, (1983)

[10]

Bors, Importance and mode of actions of antioxidants, Reactive oxygen species in medicine, pp. 161-183, (1987)

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