MODE OF ACTION OF THE ANTITUMOR COMPOUND GIRODAZOLE (RP-49532A, NSC-627434)

被引：27

作者：

COLSON, G ^{[1
]}

RABAULT, B ^{[1
]}

LAVELLE, F ^{[1
]}

ZERIAL, A ^{[1
]}

机构：

[1] RHONE POULENC RORER,CTR RECH VITRY ALFORTVILLE,13 QUAI JULES GUESDE,F-94403 VITRY,FRANCE

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 43卷 / 08期

关键词：

D O I：

10.1016/0006-2952(92)90701-J

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Girodazole (RP 49532A) or 3-amino-1-[4-(2 amino-1H-imidazolyl]-propanol, 2HCl is an experimental antitumor compound which inhibits protein synthesis in cell cultures and in cell free systems. The compound has been evaluated for its capacity to inhibit specific assays of initiation. elongation and termination of protein synthesis. Girodazole inhibited the release of nascent peptides from polyribosomes in rabbit reticulocyte lysates indicating that the major effect of the compound is on the protein synthesis termination step.

引用

页码：1717 / 1723

页数：7

共 15 条

[1]

AHOND A, 1988, CR ACAD SCI II, V307, P145

[2]

BURRES NS, 1989, CANCER RES, V49, P2935

[3] CHARACTERIZATION OF THE ELONGATION-FACTORS FROM CALF BRAIN .2. FUNCTIONAL-PROPERTIES OF EF-1-ALPHA, THE ACTION OF PHYSIOLOGICAL LIGANDS AND KIRROMYCIN [J].

CRECHET, JB ;

PARMEGGIANI, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1986, 161 (03) :647-653

[4] CHARACTERIZATION OF THE ELONGATION-FACTORS FROM CALF BRAIN .1. PURIFICATION, MOLECULAR AND IMMUNOLOGICAL PROPERTIES [J].

CRECHET, JB ;

CANCEILL, D ;

BOCCHINI, V ;

PARMEGGIANI, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1986, 161 (03) :635-645

[5]

HUANG MT, 1977, MOL PHARMACOL, V11, P511

[6]

JACKSON RJ, 1983, METHOD ENZYMOL, V96, P50

[7]

LAVELLE F, 1991, INVEST NEW DRUG, V9, P233

[8] MECHANISM OF ACTION OF 12,13-EPOXYTRICHOTHECENE, ANGUIDINE, AN INHIBITOR OF PROTEIN-SYNTHESIS [J].

LIAO, LL ;

GROLLMAN, AP ;

HORWITZ, SB .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 454 (02) :273-284

[9]

LIAO LL, 1976, MOL PHARMACOL, V12, P167

[10] EUKARYOTIC PROTEIN-SYNTHESIS [J].

MOLDAVE, K .

ANNUAL REVIEW OF BIOCHEMISTRY, 1985, 54 :1109-1149

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