GAMMAHYDROXYBUTYRATE AND NARCOLEPSY - A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY

被引:149
作者
LAMMERS, GJ
ARENDS, J
DECLERCK, AC
FERRARI, MD
SCHOUWINK, G
TROOST, J
机构
[1] KEMPENHAEGHE,DEPT CLIN NEUROPHYSIOL & POLYGRAPH,HEEZE,NETHERLANDS
[2] HOSP RIJNSTATE,DEPT NEUROL,ARNHEM,NETHERLANDS
[3] MED SPECTRUM TWENTE,DEPT NEUROL,ENSCHEDE,NETHERLANDS
[4] JANSSEN PHARMACEUT B V,TILBURG,NETHERLANDS
关键词
NARCOLEPSY; GAMMAHYDROXYBUTYRATE; POLYSOMNOGRAPHY; PLACEBO-CONTROLLED CLINICAL TRIAL;
D O I
10.1093/sleep/16.3.216
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We treated 24 patients with narcolepsy for 4 weeks with gammahydroxybutyrate (GHB), 60 mg/kg/night, in a randomized double-blind placebo-controlled cross-over trial. Both clinical and polysomnographic criteria were used to assess the results. Compared to placebo, GHB reduced the daily number of hypnagogic hallucinations (from 0.87 to 0.28; p = 0.008). daytime sleep attacks (from 2.27 to 1.40; p = 0.001) and the severity of subjective daytime sleepiness (from 1.57 to 1.24 on a 0-4 scale; p = 0.028). The number of daily cataplexy attacks was reduced from 1.26 at baseline to 0. 56 after 4 weeks of GHB intake. This reduction, however, was not statistically significantly different from the difference between baseline and placebo. GHB stabilized nocturnal rapid eye movement (REM) sleep, i.e. it reduced the percentage of wakefulness during REM sleep (p = 0.007) and the number of awakenings out of REM sleep (p = 0.016). and tended to increase slow wave sleep (p = 0.053). Adverse events were few and mild. We conclude that GHB is an effective and well-tolerated treatment for narcolepsy.
引用
收藏
页码:216 / 220
页数:5
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