THE SEQUENCES OF AND DISTANCE BETWEEN 2 CIS-ACTING SIGNALS DETERMINE THE EFFICIENCY OF RIBOSOMAL FRAMESHIFTING IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 AND HUMAN T-CELL LEUKEMIA-VIRUS TYPE-II IN-VIVO

被引：54

作者：

KOLLMUS, H

HONIGMAN, A

PANET, A

HAUSER, H

机构：

[1] GESELL BIOTECHNOL FORSCH MBH, GENET EUKARYOTES, D-38124 BRAUNSCHWEIG, GERMANY

[2] HEBREW UNIV JERUSALEM, HADASSAH MED SCH, DEPT MOLEC GENET, IL-91010 JERUSALEM, ISRAEL

[3] HEBREW UNIV JERUSALEM, HADASSAH MED SCH, DEPT VIROL, IL-91010 JERUSALEM, ISRAEL

来源：

JOURNAL OF VIROLOGY | 1994年 / 68卷 / 09期

关键词：

D O I：

10.1128/JVI.68.9.6087-6091.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have analyzed in cell culture the sequence elements that control the level of ribosomal frameshifting in the human T-cell leukemia virus type II (HTLV-2) gag-pro junction. The slippery sequence of HTLV-2 is sufficient to dictate a basal level of frameshifting. This level is enhanced by its upstream sequence context and by the downstream stem-loop structure which is located at an optimal distance of 7 bases. Frameshifting in human immunodeficiency virus gag-pol is similar to that of HTLV-2 gag-pro. However, experiments using hybrid cassettes of HTLV-2 and human immunodeficiency virus type 1 frameshift elements show that while the slippery sequence of HTLV-2 is less efficient, the stem-loop structure is a more efficient enhancer.

引用

页码：6087 / 6091

页数：5

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