EFFICACY OF QUINOLONES IN PREVENTING STAPHYLOCOCCUS AUREUS-INDUCED ABSCESS IN MICE

被引：6

作者：

COHEN, MA

GAGE, JW

HUBAND, MD

MESERVEY, MA

VANDERROEST, SR

YODER, SL

机构：

[1] Infectious Diseases Section, Parke-Davis Pharmaceutical Research, Ann Arbor, MI 48105-2495

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1995年 / 36卷 / 03期

关键词：

D O I：

10.1093/jac/36.3.551

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The new fluoroquinolones clinafloxacin, CI-990 (PD 131112/PD 131628), sparfloxacin, and PD 138312 were bactericidal against Staphylococcus aureus with MICs greater than or equal to 4-fold lower than ciprofloxacin values. In a murine subcutaneous abscess model (subcutaneous/oral dosing) the new drugs displayed protective activities against five strains which were generally higher (up to 19-fold) than ciprofloxacin values.

引用

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页码：551 / 555

页数：5

相关论文

共 10 条

[1] EMERGENT RESISTANCE TO CIPROFLOXACIN AMONGST PSEUDOMONAS-AERUGINOSA AND STAPHYLOCOCCUS-AUREUS - CLINICAL-SIGNIFICANCE AND THERAPEUTIC APPROACHES [J].

BALL, P .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1990, 26 :165-179

[2] ANTISTAPHYLOCOCCAL ACTIVITY OF THE FLUOROQUINOLONES CI-960, PD-131628, SPARFLOXACIN, OFLOXACIN AND CIPROFLOXACIN [J].

BARRY, AL ;

FUCHS, PC .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1991, 10 (03) :168-171

[3] INVITRO ANTIBACTERIAL ACTIVITIES OF THE FLUOROQUINOLONES PD-117596, PD-124816, AND PD-127391 [J].

COHEN, MA ;

HUBAND, MD ;

MAILLOUX, GB ;

YODER, SL ;

ROLAND, GE ;

HEIFETZ, CL .

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1991, 14 (03) :245-258

[4] INVITRO ANTIBACTERIAL ACTIVITIES OF PD-131628, A NEW 1,8-NAPHTHYRIDINE ANTIINFECTIVE AGENT [J].

COHEN, MA ;

HUBAND, MD ;

MAILLOUX, GB ;

YODER, SL ;

ROLAND, GE ;

DOMAGALA, JM ;

HEIFETZ, CL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (01) :141-146

[5] IN-VITRO ANTIBACTERIAL ACTIVITIES OF PD 138312 AND PD 140248, NEW FLUORONAPHTHYRIDINES WITH OUTSTANDING GRAM-POSITIVE POTENCY [J].

HUBAND, MD ;

COHEN, MA ;

MESERVEY, MA ;

ROLAND, GE ;

YODER, SL ;

DAZER, ME ;

DOMAGALA, JM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (12) :2563-2570

[6] INVITRO AND INVIVO ANTIBACTERIAL ACTIVITIES OF AT-4140, A NEW BROAD-SPECTRUM QUINOLONE [J].

NAKAMURA, S ;

MINAMI, A ;

NAKATA, K ;

KUROBE, N ;

KOUNO, K ;

SAKAGUCHI, Y ;

KASHIMOTO, S ;

YOSHIDA, H ;

KOJIMA, T ;

OHUE, T ;

FUJIMOTO, K ;

NAKAMURA, M ;

HASHIMOTO, M ;

SHIMIZU, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (08) :1167-1173

[7] EMERGENCE OF CIPROFLOXACIN RESISTANCE IN NOSOCOMIAL METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS ISOLATES - RESISTANCE DURING CIPROFLOXACIN PLUS RIFAMPIN THERAPY FOR METHICILLIN-RESISTANT S-AUREUS COLONIZATION [J].

PETERSON, LR ;

QUICK, JN ;

JENSEN, B ;

HOMANN, S ;

JOHNSON, S ;

TENQUIST, J ;

SHANHOLTZER, C ;

PETZEL, RA ;

SINN, L ;

GERDING, DN .

ARCHIVES OF INTERNAL MEDICINE, 1990, 150 (10) :2151-2155

[8]

SESNIE JC, 1988, 88TH ANN M AM SOC MI, P3

[9]

SESNIE JC, 1991, 31ST INT C AT AGE CH, P347

[10]

SHAPIRO MA, 1993, 33RD INT C ANT AG CH, P306