EFFECTS OF CAFFEINE AND PD-116,600 ON THE DIFFERENTIAL-REINFORCEMENT-OF-LOW RATE 72-S (DRL 72-S) SCHEDULE OF REINFORCEMENT

被引：6

作者：

MAREK, GJ ^{[1
]}

HEFFNER, TG ^{[1
]}

RICHARDS, JB ^{[1
]}

SHAUGHNESSY, RA ^{[1
]}

LI, AA ^{[1
]}

SEIDEN, LS ^{[1
]}

机构：

[1] UNIV CHICAGO,DEPT PHARMACOL & PHYSIOL SCI,947 E 58TH ST,CHICAGO,IL 60637

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1993年 / 45卷 / 04期

关键词：

CAFFEINE; PD-116,600; ANTIDEPRESSANT DRUGS; BEHAVIORAL SCREEN; DRL 72-S SCHEDULE; ADENOSINE ANTAGONISTS; PSYCHOMOTOR STIMULANTS;

D O I：

10.1016/0091-3057(93)90153-K

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Caffeine and PD 116,600 were found to decrease the reinforcement rate and increase the response rate in rats performing under a differential-reinforcement-of-low rate 72-s (DRL 72-s) schedule of reinforcement. In contrast, antidepressant drugs previously have been found to increase the reinforcement and decrease the response rate. Caffeine has been found to test similar to antidepressant drugs on at least one other behavioral screen, but caffeine does not possess clinical antidepressant properties. These results provide further support for the DRL 72-s schedule as a behavioral screen for antidepressant drugs.

引用

页码：987 / 990

页数：4

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