NEUROPEPTIDE-Y MICROINJECTED INTO THE SUPRACHIASMATIC REGION PHASE-SHIFTS CIRCADIAN-RHYTHMS IN CONSTANT DARKNESS

被引:105
作者
HUHMAN, KL
ALBERS, HE
机构
[1] GEORGIA STATE UNIV,DEPT BIOL,NEUROENDOCRINOL & BEHAV LAB,ATLANTA,GA 30303
[2] GEORGIA STATE UNIV,DEPT PSYCHOL,ATLANTA,GA 30303
关键词
GENICULOHYPOTHALAMIC TRACT; INTERGENICULATE LEAFLET; NEUROPEPTIDE Y; HAMSTER; NONPHOTIC;
D O I
10.1016/0196-9781(94)90126-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The geniculohypothalamic tract (GHT) is a projection from the intergeniculate leaflet to the suprachiasmatic nucleus (SCN). The GHT exhibits neuropeptide Y (NPY) immunoreactivity and appears to communicate photic information to the SCN. Microinjection of NPY into the SCN has been found to phase shift circadian rhythms of hamsters housed in constant light in a manner similar to the phase shifts produced by pulses of darkness or triazolam injections. In the present study, NPY was injected into the SCN of Syrian hamsters housed in constant darkness and was found to produce phase shifts similar to those seen in hamsters housed in constant light. Microinjections were not followed by wheel running during the subjective day (the time when NPY microinjections are followed by significant phase advances). These data suggest that NPY produces phase shifts by some mechanism other than by inducing wheel running or by inhibiting the response of SCN neurons to light and supports a role for NPY in nonphotic shifting of the circadian clock.
引用
收藏
页码:1475 / 1478
页数:4
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