EFFECT OF 3 MONTHS NASAL STEROID-THERAPY ON NASAL T-CELLS AND LANGERHANS CELLS IN PATIENTS SUFFERING FROM ALLERGIC RHINITIS

被引:56
作者
HOLM, AF
FOKKENS, WJ
GODTHELP, T
MULDER, PG
VROOM, TM
RIJNTJES, E
机构
[1] ERASMUS UNIV ROTTERDAM,DEPT IMMUNOL,ROTTERDAM,NETHERLANDS
[2] ERASMUS UNIV ROTTERDAM,DEPT BIOSTAT,ROTTERDAM,NETHERLANDS
[3] UNIV UTRECHT HOSP,DEPT PATHOL,UTRECHT,NETHERLANDS
[4] LEYENBURG HOSP,DEPT OTORHINOLARYNGOL,THE HAGUE,NETHERLANDS
关键词
CORTICOSTEROIDS; LANGERHANS CELL; RHINITIS; T CELL;
D O I
10.1111/j.1398-9995.1995.tb01134.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The effect of nasal corticosteroid therapy on allergic rhinitis is uncertain. In a double-blind, placebo-controlled study over 3 months, we investigated the influence of a new corticosteroid spray, fluticasone propionate aqueous nasal spray (FPANS), on Langerhans cells (CD1a(+) cells), HLA-DR(+) cells, and T cells in nasal mucosa. Efficacy was evaluated by nasal symptom score. This treatment significantly decreased the number of CD1a(+) cells and HLA-DR(+) cells in the nasal mucosa. Furthermore, a clear trend of decreasing numbers of T cells in nasal epithelium was found. No change in nasal symptom score was found after the treatment period. These findings suggest that fluticasone propionate aqueous nasal spray decreases the antigen presentation in nasal allergy.
引用
收藏
页码:204 / 209
页数:6
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