GENETIC SUSCEPTIBILITY TO ALZHEIMER-DISEASE

被引：106

作者：

PERICAKVANCE, MA ^{[1
]}

HAINES, JL ^{[1
]}

机构：

[1] MASSACHUSETTS GEN HOSP,MOLEC NEUROGENET UNIT,BOSTON,MA

来源：

TRENDS IN GENETICS | 1995年 / 11卷 / 12期

关键词：

D O I：

10.1016/S0168-9525(00)89161-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Alzheimer disease (AD) is the leading cause of dementia in the elderly. Less than a decade ago, it was questioned as to whether or not genes were even involved in anything but rare early onset AD. Since that time, using a variety of genetic epidemiological and molecular biological techniques, four loci have been identified that play a role in the genetic susceptibility of AD. AD presents as a prototype of the power of genetic techniques in defining the etiology of a complex disease.

引用

页码：504 / 508

页数：5

共 62 条

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