MUCIN-ASSOCIATED ANTIGENS AS MARKERS OF GASTROINTESTINAL DIFFERENTIATION AND CARCINOGENESIS

被引：1

作者：

BALDUS, SE ^{[1
]}

HANISCH, FG ^{[1
]}

机构：

[1] UNIV COLOGNE,INST IMMUNBIOL,COLOGNE,GERMANY

来源：

PATHOLOGE | 1995年 / 16卷 / 02期

关键词：

GLYCOPROTEIN; CARBOHYDRATE ANTIGEN; CARCINOMA; ADENOMACARCINOMA SEQUENCE; IMMUNOHISTOCHEMISTRY;

D O I：

10.1007/s002920050082

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Mucins are heavily glycosylated glycoproteins which exhibit a variety of antigenic determinants consisting of carbohydrates and/or peptide sequences. The application of monoclonal antibodies and lectins in immunohistochemistry resulted in a considerable extension of knowledge regarding their topography during I histogenesis. Additionally, typical alterations of antigenic profiles during neoplastic transformation of cells and tissues were described. A number of new results are in keeping with the assumption that mucin-associated antigens play an important role in tumor biology, for example metastasis, and as markers of prognosis. The purpose of the present paper is to give a review, including the authors' own results, of knowledge on the gastrointestinal mucin antigens in experimental and clinical pathology.

引用

页码：94 / 105

页数：12

共 82 条

[41] MUCIN ASSOCIATED TN AND SIALOSYL-TN ANTIGEN EXPRESSION IN COLORECTAL POLYPS [J].