SITE OF ANTIINFLAMMATORY ACTION OF DEXAMETHASONE IN RABBIT SKIN

被引：10

作者：

PEERS, SH ^{[1
]}

FLOWER, RJ ^{[1
]}

机构：

[1] UNIV BATH,PHARMACOL GRP,BATH BA2 8AY,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 196卷 / 01期

基金：

英国惠康基金;

关键词：

DEXAMETHASONE; ACUTE INFLAMMATION; ACTINOMYCIN-D;

D O I：

10.1016/0014-2999(91)90406-G

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Systemic pretreatment of rabbits with dexamethasone results in a time-dependent inhibition of oedema responses caused by intradermal injection of both 'direct-acting' and 'neutrophil-dependent' stimuli. Local injection of actinomycin D, an inhibitor of RNA synthesis, inhibits this effect. Our studies suggest that a major action of dexamethasone in this model may be a local inhibition of increased permeability of the vascular endothelium.

引用

页码：37 / 41

页数：5

共 27 条

[1] SELECTIVE-INHIBITION BY VASOCORTIN OF HISTAMINE-RELEASE INDUCED BY DEXTRAN AND CONCANAVALIN-A FROM RAT PERITONEAL-CELLS [J].

CARNUCCIO, R ;

DIROSA, M ;

IALENTI, A ;

IUVONE, T ;

SAUTEBIN, L .

BRITISH JOURNAL OF PHARMACOLOGY, 1989, 98 (01) :32-34

[2] HUMAN RECOMBINANT LIPOCORTIN-1 HAS ACUTE LOCAL ANTI-INFLAMMATORY PROPERTIES IN THE RAT PAW EDEMA TEST [J].

CIRINO, G ;

PEERS, SH ;

FLOWER, RJ ;

BROWNING, JL ;

PEPINSKY, RB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (09) :3428-3432

[3] A PURIFIED LIPOCORTIN SHARES THE ANTI-INFLAMMATORY EFFECT OF GLUCOCORTICOSTEROIDS INVIVO IN MICE [J].

ERRASFA, M ;

RUSSOMARIE, F .

BRITISH JOURNAL OF PHARMACOLOGY, 1989, 97 (04) :1051-1058

[4] 11TH GADDUM MEMORIAL LECTURE - LIPOCORTIN AND THE MECHANISM OF ACTION OF THE GLUCOCORTICOIDS [J].

FLOWER, RJ .

BRITISH JOURNAL OF PHARMACOLOGY, 1988, 94 (04) :987-1015

[5] ANTAGONISM OF PAF-INDUCED EDEMA FORMATION IN RABBIT SKIN - A COMPARISON OF DIFFERENT ANTAGONISTS [J].

HELLEWELL, PG ;

WILLIAMS, TJ .

BRITISH JOURNAL OF PHARMACOLOGY, 1989, 97 (01) :171-180

[6]

HIGGS GA, 1979, BIOCHEM PHARMACOL, V28, P1979

[7] A PHOSPHOLIPASE-A2 INHIBITORY PROTEIN IN RABBIT NEUTROPHILS INDUCED BY GLUCOCORTICOIDS [J].

HIRATA, F ;

SCHIFFMANN, E ;

VENKATASUBRAMANIAN, K ;

SALOMON, D ;

AXELROD, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (05) :2533-2536

[8]

JASANI MK, 1979, HDB EXP PHARM, V50, P598

[9]

LEWIS RE, 1986, FED PROC, V45, P109

[10] GLUCOCORTICOID-INDUCED VASOCONSTRICTION IN HUMAN-SKIN - AN INHIBITORY ROLE ON PHOSPHOLIPASE-A2 ACTIVITY [J].

MARKS, R ;

SAWYER, M .

ARCHIVES OF DERMATOLOGY, 1986, 122 (08) :881-883

← 1 2 3 →