FINAL HEIGHT IN TURNER SYNDROME PATIENTS TREATED WITH GROWTH-HORMONE

被引:42
作者
ROCHICCIOLI, P
BATTIN, J
BERTRAND, AM
BOST, M
CABROL, S
LEBOUC, Y
CHAUSSAIN, JL
CHATELAIN, P
COLLE, M
CZERNICHOW, P
DAVID, M
JOB, JC
LECORNU, M
LEHEUP, B
PIERSON, M
LIMAL, JM
MARIANI, R
PONTE, C
RAPPAPORT, R
TAUBER, M
机构
[1] HOP ENFANTS, BORDEAUX, FRANCE
[2] CTR HOSP, BESANCON, FRANCE
[3] CHU LATRONCHE, GRENOBLE, FRANCE
[4] HOP TROUSSEAU, F-75571 PARIS, FRANCE
[5] HOP ST VINCENT DE PAUL, F-75674 PARIS, FRANCE
[6] HOP DEBROUSSE, LYON, FRANCE
[7] HOP ROBERT DEBRE, F-75019 PARIS, FRANCE
[8] HOP LYON SUD, LYON, FRANCE
[9] CHU RENNES, RENNES, FRANCE
[10] CHU NANCY, NANCY, FRANCE
[11] CHU ANGERS, ANGERS, FRANCE
[12] HOP CIMIEZ, F-06003 NICE, FRANCE
[13] HOP CALMETTE, LILLE, FRANCE
[14] HOP NECKER ENFANTS MALAD, PARIS, FRANCE
关键词
TURNER SYNDROME; FINAL HEIGHT; GROWTH HORMONE; THERAPY;
D O I
10.1159/000184620
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The first treatment trials on patients presenting with Turner syndrome were successful in accelerating growth velocity, It is therefore essential to know the final height of the patients who were treated in order to ascertain whether or not growth hormone treatment increases final height, We are reporting on a group of 117 patients with Turner syndrome whose growth hormone treatment was initiated in 1986, The mean growth hormone dose was 0.74IU/kg/week for an average period of 4 years. At the start of treatment, the patients' chronological age was 12 9/12 years, height -3.8 +/- 1.0 standard deviation scores (SDS) and bone age 10.5 +/- 2.1 years, Mean final height was 147.7 +/- 5.6 cm, i,e, a gain of 1.5 SDS, We noted no significant difference due to the type of chromosomal abnormality, nor to oxandrolone or estrogen-associated treatment, A significant correlation was found between final height, mean parental height, the duration of the treatment, height SIDS at the start. of treatment and growth hormone peak during pharmacological stimulation tests, However, there was no correlation between growth hormone dosage, chronological age and bone age at the start of treatment, These results show that the growth hormone treatment improves the final heights of patients with Turner syndrome.
引用
收藏
页码:172 / 176
页数:5
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