INHIBITION OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE OBTAINED FROM GUINEA-PIG KIDNEY BY FUROSEMIDE, NARINGENIN AND SOME OTHER COMPOUNDS

被引:37
作者
ZHANG, YD
LORENZO, B
REIDENBERG, MM
机构
[1] CORNELL UNIV,COLL MED,DEPT PHARMACOL,NEW YORK,NY 10021
[2] CORNELL UNIV,COLL MED,DEPT MED,NEW YORK,NY 10021
关键词
D O I
10.1016/0960-0760(94)90304-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Inhibition of 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) can cause excess mineralocorticoid effects and hypokalemia, Several substances causing hypokalemia (glycyrrhizic acid in licorice and gossypol) inhibit this enzyme. We tested other compounds for activity to inhibit 11 beta-OHSD in guinea pig kidney cortex microsomes with NADP as cofactor and cortisol as substrate. Furosemide was an inhibitor while bumetanide was not, indicating a mechanism for the increased K+ excretion caused by furosemide compared with bumetanide. Naringenin (found in grapefruit juice), ethacrynic acid, and chenodeoxycholic acid had inhibitor IC50 values similar to glycyrrhizic acid. We conclude that various compounds can inhibit this enzyme and may play a role in K+ metabolism and adrenocorticosteroid action.
引用
收藏
页码:81 / 85
页数:5
相关论文
共 26 条
[1]   BUMETANIDE - POTENT NEW LOOP DIURETIC [J].
ASBURY, MJ ;
BOURKE, E ;
OSULLIAN, S ;
GATENBY, PBB .
BRITISH MEDICAL JOURNAL, 1972, 1 (5794) :211-&
[2]   INTERACTION OF CITRUS JUICES WITH FELODIPINE AND NIFEDIPINE [J].
BAILEY, DG ;
SPENCE, JD ;
MUNOZ, C ;
ARNOLD, JMO .
LANCET, 1991, 337 (8736) :268-269
[3]   ELECTROLYTE EXCRETION PATTERNS - INTRAVENOUS AND ORAL DOSES OF BUMETANIDE COMPARED TO FUROSEMIDE [J].
BRATER, DC ;
FOX, WR ;
CHENNAVASIN, P .
JOURNAL OF CLINICAL PHARMACOLOGY, 1981, 21 (11-1) :599-603
[4]   BUMETANIDE AND FUROSEMIDE IN HEART-FAILURE [J].
BRATER, DC ;
DAY, B ;
BURDETTE, A ;
ANDERSON, S .
KIDNEY INTERNATIONAL, 1984, 26 (02) :183-189
[5]   INHIBITION OF RAT RENAL 11-BETA-HYDROXYSTEROID DEHYDROGENASE BY STEROIDAL COMPOUNDS AND TRITERPENOIDS - STRUCTURE-FUNCTION RELATIONSHIP [J].
BUHLER, H ;
PERSCHEL, FH ;
HIERHOLZER, K .
BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1075 (03) :206-212
[6]   LESSONS FROM LICORICE [J].
EDWARDS, CRW .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (17) :1242-1243
[7]   CONGENITAL AND ACQUIRED SYNDROMES OF APPARENT MINERALOCORTICOID EXCESS [J].
EDWARDS, CRW ;
WALKER, BR ;
BENEDIKTSSON, R ;
SECKL, JR .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1993, 45 (1-3) :1-5
[8]   APPARENT MINERALOCORTICOID EXCESS, PSEUDOHYPOALDOSTERONISM, AND URINARY ELECTROLYTE EXCRETION - TOWARD A REDEFINITION OF MINERALOCORTICOID ACTION [J].
FUNDER, JW ;
PEARCE, PT ;
MYLES, K ;
ROY, LP .
FASEB JOURNAL, 1990, 4 (14) :3234-3238
[9]  
Kuhnau J, 1976, World Rev Nutr Diet, V24, P117
[10]   LOCALIZATION OF AN 11-BETA HYDROXYSTEROID DEHYDROGENASE-ACTIVITY TO THE DISTAL NEPHRON - EVIDENCE FOR THE EXISTENCE OF 2 SPECIES OF DEHYDROGENASE IN THE RAT-KIDNEY [J].
MERCER, WR ;
KROZOWSKI, ZS .
ENDOCRINOLOGY, 1992, 130 (01) :540-543