CLEARANCE OF CHRONIC HEPATITIS-B VIRUS-INFECTION IN YOUNG-CHILDREN AFTER ALPHA-INTERFERON TREATMENT

被引：26

作者：

NARKEWICZ, MR

SMITH, D

SILVERMAN, A

VIERLING, J

SOKOL, RJ

机构：

[1] UNIV COLORADO, SCH MED, DEPT PEDIAT, PEDIAT GASTROENTEROL SECT, DENVER, CO USA

[2] UNIV COLORADO, SCH MED, PEDIAT LIVER CTR, DENVER, CO USA

[3] UNIV COLORADO, SCH MED, HEPATOBILIARY RES CTR, DENVER, CO USA

[4] CEDARS SINAI MED CTR, DEPT MED, LOS ANGELES, CA 90048 USA

来源：

JOURNAL OF PEDIATRICS | 1995年 / 127卷 / 05期

关键词：

D O I：

10.1016/S0022-3476(95)70181-8

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Nine children aged 18 months to 17 years (mean, 5.7 years) with chronic hepatitis B virus infection and chronic active hepatitis were treated with 5 to 6 million units/m(2) of body surface area of interferon-alpha 2b administered subcutaneously three times per week for 4 months (n = 1) or 6 months (n = 8). At 12 months after the start of therapy, six children less than 3 years of age responded to the treatment (three completely and three partially), whereas only one of three children older than 7 years of age responded. We conclude that IFN treatment may be effective in children with chronic HBV infection, especially when administered while they are young.

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页码：815 / 818

页数：4

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