INHIBITION BY GOSSYPOL OF TESTOSTERONE PRODUCTION BY MOUSE LEYDIG-CELLS INVITRO

被引：18

作者：

DONALDSON, A ^{[1
]}

SUFI, SB ^{[1
]}

JEFFCOATE, SL ^{[1
]}

机构：

[1] CHELSEA HOSP WOMEN, DEPT BIOCHEM ENDOCRINOL, DOVEHOUSE ST, LONDON SW3 6LT, ENGLAND

来源：

CONTRACEPTION | 1985年 / 31卷 / 02期

关键词：

D O I：

10.1016/0010-7824(85)90030-7

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Gossypol, a polyphenolic compound prepared from cottonseed, has potential uses as a male contraceptive. It inhibits spermatogenesis and sperm motility but has toxic side effects and furthermore may have effects on endocrine function though evidence for this is contradictory. Gossypol had a dose-dependent inhibitory action on release of testosterone from dispersed mouse Leydig cells. Doses down to 20 .mu.M and 10 .mu.M significantly inhibited unstimulated and LH-stimulated release, respectively.

引用

页码：165 / 171

页数：7

共 15 条

[1] AN ANALYSIS OF THE DIRECT EFFECTS OF GOSSYPOL ON HUMAN-SPERMATOZOA [J].

AITKEN, RJ ;

LIU, J ;

BEST, FSM ;

RICHARDSON, DW .

INTERNATIONAL JOURNAL OF ANDROLOGY, 1983, 6 (02) :157-167

[2] ANTI-FERTILITY AND ENDOCRINE ACTIVITIES OF GOSSYPOL IN RODENTS [J].

HAHN, DW ;

RUSTICUS, C ;

PROBST, A ;

HOMM, R ;

JOHNSON, AN .

CONTRACEPTION, 1981, 24 (01) :97-105

[3]

KALLA NR, 1983, J ANDROL, V4, P331

[4]

LIN T, 1981, FERTIL STERIL, V35, P563

[5]

Liu B., 1957, SHANGHAI J CHIN MED, V6, P43

[6]

LIU YC, 1980, BIOL REPROD, V22, pA95

[7] EFFECT OF LH ON STEROIDOGENESIS AND CYCLIC-AMP ACCUMULATION IN RAT LEYDIG CELL PREPARATIONS AND MOUSE TUMOR LEYDIG CELLS [J].

MOYLE, WR ;

RAMACHANDRAN, J .

ENDOCRINOLOGY, 1973, 93 (01) :127-134

[8]

PRASAD MRM, 1984, FERTIL STERIL, P255

[9] GOSSYPOL - A POTENTIAL ANTIFERTILITY AGENT FOR MALES [J].

QIAN, SZ ;

WANG, ZG .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1984, 24 :329-360

[10]

Qian SZ, 1980, CLIN PHARMACOL THER, P489

← 1 2 →