DIMERS, LEUCINE ZIPPERS AND DNA-BINDING DOMAINS

被引：376

作者：

BUSCH, SJ

SASSONECORSI, P

机构：

[1] S.J. Busch and P. Sassone-Corsi are in the Laboratoire de Genetique Moleculaire des Eucaryotes, CNRS, Unité 184 de l'INSERM, 67085 Strasbourg Cédex, 11, rue Humann

来源：

TRENDS IN GENETICS | 1990年 / 6卷 / 02期

关键词：

D O I：

10.1016/0168-9525(90)90071-D

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Transcription factors can be divided into classes on the basis of their mode of interaction with the target promoter sequence. Different protein domains responsible for DNA recognition have been identified. In this review we discuss the leucine zipper structure, which has been found in several nuclear factors, including the oncoproteins Fos and Jun. Structural considerations are summarized to help understand how dimerization is mediated by the leucine zipper and how this is the prerequisite for optimal target DNA recognition by the adjacent basic domains. © 1990.

引用

页码：36 / 40

页数：5

共 32 条

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